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Chamberlain was a standout wide receiver at Wayne State from 1993-94, leading to a successful nine-year career in the National Football League. In his two seasons with the Wildcats, Chamberlain had 161 catches for 1,941 yards and 14 touchdowns and became the school's all-time leading receiver, holding the record until Logan Masters became the all-time receptions leader in 2008. In 1993, Chamberlain had 78 catches for 1,015 yards and seven touchdowns to help the 9-1 Wildcats lead NCAA Division II in total offense that season. He added another 83 catches for 926 yards in 1994. The 83 catches are the second most in a single season by a Wildcat receiver and his 16 catches vs. Bemidji State that season ranks second most in a single game by a WSC receiver. Chamberlain then went on to a successful nine-year career in the National Football League, starting with the Denver Broncos. In 2001, Chamberlain had 57 catches for 666 yards with the Minnesota Vikings to earn NFL Pro Bowl honors at tight end. He finished his NFL career with 167 receptions for 2,048 yards and six touchdowns, averaging 12.3 yards per catch.