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| The Acute Metabolic and Hormonal Effects of Sitting and Standing |
Importance of Study
Currently, research shows that
standing increases energy expenditure by 10 cals/hour. Observational studies
also show that individuals, who are less sedentary throughout the day but take
more interruptions from sedentary behavior, have greater metabolic health
compared to sedentary individuals. However, it is not known if standing is
metabolically healthier and if there are acute metabolic and hormonal changes that
occur after just 1 day of standing. Our study will examine how insulin,
glucose, triglycerides, HDL, and the appetite hormones leptin and ghrelin are affected
by standing vs. sitting.
- Male or female between the ages of
25 to 70
- Elevated Triglyceride levels (≥150)
and waist circumference- females ≥ 35” males ≥ 40”
- Not taking any lipid or glucose
lowering medication
- Not having a physically active occupation
Experimental
Protocol
The experimental days will be held
in March or April on two consecutive Saturdays. The experimental days will consist of
either an 8 hour standing day (standing 40-50 mins/hour and sitting 10-15
mins/hour) or an 8 hour sitting day (sitting 40-50 mins/hour and standing
10-15 mins/hour). Office activities will be performed throughout the day. Heart
rate and blood pressure will be measured throughout the experimental day. Small
blood samples will also be taken to measure metabolic and hormonal changes.
Subject’s Rewards
- Contribution
to medical knowledge
- $150
Visa Card after completing all study procedures
- Insulin
resistance and glucose testing
- Measurements
of triglycerides, High Density Lipoproteins (HDL), leptin and ghrelin levels (apetite hormones)
- Measurements
of daily living activity, standing, and sitting levels
- Resting
energy expenditure and activity energy expenditure requirements